PADI1

Across TCGA patient cohorts, PADI1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PADI1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and P-Cadherin. Each is linked with PADI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PADI1-to-partner and partner-to-PADI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PADI1-low versus PADI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI1→partner) and Y-score (partner→PADI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.288	-1.925	.001	.005	3	2
UCEC	ERK2 →	+0.212	+2.807	.002	.002	3	2
SKCM	P-Cadherin →	-0.266	-3.321	.022	.009	3	2
SKCM	Shc_pY317 →	-0.191	-2.567	.029	.011	3	2
COAD	Chk1_pS345 →	+0.116	+2.824	.033	.034	3	2
UCEC	14-3-3_beta →	-0.091	-1.973	.011	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by PADI1 expression — UCEC

Explore this box plot interactively →