PADI1

Across TCGA cell cohorts, PADI1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PADI1-associated genes across cancer lineages are TYROBP, CCL25, and CCL14. Each is linked with PADI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PADI1-to-partner and partner-to-PADI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYROBP grouped by PADI1-low versus PADI1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI1→partner) and Y-score (partner→PADI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TYROBP →	+0.265	+3.554	<.001	.007	3	1
SKIN	CCL25 →	+0.075	+3.510	<.001	.003	3	1
SKIN	CCL14 →	+0.095	+3.510	<.001	.003	3	1
SKIN	SLC4A1 →	+0.241	+3.453	<.001	.009	3	1
CNS	FHL5 →	+0.019	+4.044	<.001	.003	3	1
CNS	APOL5 →	+0.033	+3.978	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TYROBP by PADI1 expression — SKIN

Explore this box plot interactively →