PACSIN3

Across TCGA cell cohorts, PACSIN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,384 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PACSIN3-associated GO terms across cancer lineages are Positive regulation of membrane protein ectodomain proteolysis, DTMP biosynthetic process, and Pyrimidine deoxyribonucleoside monophosphate biosynthetic process. Each is linked with PACSIN3 in more than 10 cancer types. Because this analysis shows association rather than direction, both PACSIN3-to-partner and partner-to-PACSIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of membrane protein ectodomain proteolysis grouped by PACSIN3-low versus PACSIN3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN3→partner) and Y-score (partner→PACSIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of membrane protein ectodomain proteolysis →	+0.187	+1.164	<.001	.003	2	11
BLOOD_Leukemia	DTMP biosynthetic process →	+0.057	+1.075	.003	.003	3	8
BLOOD_Leukemia	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.057	+1.075	.003	.003	3	8
CNS	UDP biosynthetic process →	+0.069	+0.902	.007	<.001	3	7
CNS	Pyrimidine ribonucleoside diphosphate biosynthetic process →	+0.069	+0.902	.007	<.001	3	7
SOFT_TISSUE	Pyruvate import into mitochondria →	-0.145	-1.093	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,384 associations by consensus.

Positive regulation of membrane protein ectodomain proteolysis by PACSIN3 expression — BREAST

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