PACSIN3

Across TCGA cell cohorts, PACSIN3 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,207 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PACSIN3-associated GO terms across cancer lineages are Negative regulation of vasculature development, Positive regulation of extracellular matrix organization, and Positive regulation of focal adhesion assembly. Each is linked with PACSIN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PACSIN3-to-partner and partner-to-PACSIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of vasculature development grouped by PACSIN3-low versus PACSIN3-high in KIDNEY.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN3→partner) and Y-score (partner→PACSIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of vasculature development →	+0.151	+1.227	.001	.002	3	5
BREAST	Positive regulation of extracellular matrix organization →	+0.177	+1.318	<.001	.001	3	4
OVARY	Positive regulation of focal adhesion assembly →	+0.123	+1.580	.006	.006	3	4
KIDNEY	Negative regulation of angiogenesis →	+0.149	+1.227	.001	.002	3	4
KIDNEY	Regulation of cell-matrix adhesion →	+0.091	+1.014	<.001	<.001	3	4
KIDNEY	Negative regulation of blood vessel morphogenesis →	+0.150	+1.227	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,207 associations by consensus.

Negative regulation of vasculature development by PACSIN3 expression — KIDNEY

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