PACSIN2

Across TCGA patient cohorts, PACSIN2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACSIN2-associated genes across cancer lineages are Caspase-7-cleavedD198, STAT3_pY705, and p27_pT198. Each is linked with PACSIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PACSIN2-to-partner and partner-to-PACSIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PACSIN2-low versus PACSIN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACSIN2→partner) and Y-score (partner→PACSIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.153	+2.824	.001	.034	3	3
COAD	STAT3_pY705 →	-0.269	-3.450	.022	.005	3	2
UCEC	p27_pT198 →	+0.094	+1.906	.028	.016	3	1
UCEC	p62 Lck ligand →	+0.313	+3.331	.016	.005	3	1
UCEC	PCNA →	+0.225	+3.169	.009	.018	3	1
UCEC	Rad50 →	-0.223	-1.906	.022	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by PACSIN2 expression — COAD

Explore this box plot interactively →