PACS2

Across TCGA patient cohorts, PACS2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACS2-associated genes across cancer lineages are ATM, INPP4B, and cIAP. Each is linked with PACS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PACS2-to-partner and partner-to-PACS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PACS2-low versus PACS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS2→partner) and Y-score (partner→PACS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.573	-2.459	<.001	<.001	3	3
UCEC	INPP4B →	-0.314	-3.584	.005	.002	3	2
UCEC	cIAP →	+0.102	+2.096	.032	.001	3	2
UCEC	4E-BP1 →	+0.265	+1.440	.004	.024	3	2
COAD	GAPDH →	+0.586	+2.815	.035	.036	3	2
UCEC	14-3-3_beta →	-0.086	-3.432	.014	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by PACS2 expression — UCEC

Explore this box plot interactively →