PACS2

Across TCGA cell cohorts, PACS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,670 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PACS2-associated GO terms across cancer lineages are Regulation of protein localization to endoplasmic reticulum, Mitochondrion-endoplasmic reticulum membrane tethering, and Cilium-dependent cell motility. Each is linked with PACS2 in more than 17 cancer types. Because this analysis shows association rather than direction, both PACS2-to-partner and partner-to-PACS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to endoplasmic reticulum grouped by PACS2-low versus PACS2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS2→partner) and Y-score (partner→PACS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of protein localization to endoplasmic reticulum →	+0.143	+1.082	<.001	<.001	3	18
BREAST	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.138	+0.992	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.108	-0.941	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.108	-0.941	<.001	<.001	3	18
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.102	+1.011	<.001	<.001	3	17
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.158	+0.902	<.001	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,670 associations by consensus.

Regulation of protein localization to endoplasmic reticulum by PACS2 expression — URINARY_TRACT

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