PACS2

Across TCGA cell cohorts, PACS2 mutation is significantly associated with the RNA expression of many other genes, with 494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PACS2-associated genes across cancer lineages are OR52B2, UTF1, and PICK1. Each is linked with PACS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACS2-to-partner and partner-to-PACS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52B2 grouped by PACS2-low versus PACS2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS2→partner) and Y-score (partner→PACS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR52B2 →	+0.036	+4.080	.002	.001	3	2
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	2
LARGE_INTESTINE	PICK1 →	+0.708	+3.212	.003	.006	3	1
LARGE_INTESTINE	TRIP11 →	+0.670	+3.212	<.001	.006	3	1
LARGE_INTESTINE	USP14 →	+0.722	+3.237	.002	.003	3	1
LARGE_INTESTINE	RIOK3 →	+0.882	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 494 associations by consensus.

OR52B2 by PACS2 expression — BREAST

Explore this box plot interactively →