PACS1

Across TCGA pan-cancer cohorts, PACS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PACS1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PACS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PACS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where PACS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.838	0.432	.001	13	view →
COAD	DFS	Median	III,IV	0.826	1.000	.023	12	view →
PDAC	DFS	Quartile	II,III,IV	0.823	0.699	.017	5	view →
GBM	DFS	Quartile	All	0.521	0.270	.018	4	view →
UCEC	DFS	Median	All	0.948	0.861	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PACS1–CCRCC (DFS)

Open the CCRCC breakdown →