PACS1

Across TCGA patient cohorts, PACS1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,824 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PACS1-associated genes across cancer lineages are ZCCHC24, NAP1L3, and SCN7A. Each is linked with PACS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PACS1-to-partner and partner-to-PACS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PACS1 versus ZCCHC24 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS1→partner) and Y-score (partner→PACS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZCCHC24 →	+0.869	+0.212	.002	.007	3	7
GBM	NAP1L3 →	+0.911	+0.264	<.001	<.001	3	7
LUAD	SCN7A →	+1.015	+0.121	<.001	.004	3	6
GBM	PABPC5 →	+0.617	+0.173	.005	.001	3	6
OV	ITM2A →	+1.238	+0.270	<.001	.003	3	6
LSCC	CDC25A →	-0.766	-0.207	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,824 associations by consensus.

PACS1 vs ZCCHC24 — BRCA

Explore this scatter interactively →