PACS1

Across TCGA patient cohorts, PACS1 mutation is significantly associated with the RNA expression of many other genes, with 2,933 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACS1-associated genes across cancer lineages are MIR3121, L3MBTL2, and DESI1. Each is linked with PACS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PACS1-to-partner and partner-to-PACS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3121 grouped by PACS1-low versus PACS1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS1→partner) and Y-score (partner→PACS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3121 →	+0.566	+4.548	<.001	.001	3	3
UCEC	L3MBTL2 →	+0.356	+1.765	<.001	<.001	3	2
SKCM	DESI1 →	+0.356	+2.689	.006	.004	3	2
SKCM	PLA2G15 →	+0.468	+2.508	.007	.001	3	2
SKCM	PIN1 →	+0.341	+3.478	.006	.002	3	2
SKCM	EPS15L1 →	+0.313	+2.719	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,933 associations by consensus.

MIR3121 by PACS1 expression — LUSC

Explore this box plot interactively →