PACS1

Across TCGA patient cohorts, PACS1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACS1-associated genes across cancer lineages are A-Raf_pS299, p27_pT198, and Akt_pT308. Each is linked with PACS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACS1-to-partner and partner-to-PACS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PACS1-low versus PACS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS1→partner) and Y-score (partner→PACS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.157	-3.807	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.106	+1.459	.002	.012	3	2
UCEC	Akt_pT308 →	+0.486	+2.000	.017	.029	3	2
UCEC	S6_pS240_S244 →	+0.324	+1.222	.014	.035	3	2
UCEC	AR →	-0.268	-1.222	.026	.035	3	2
UCEC	14-3-3_beta →	-0.121	-3.060	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

A-Raf_pS299 by PACS1 expression — UCEC

Explore this box plot interactively →