PACS1

Across TCGA cell cohorts, PACS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,768 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PACS1-associated GO terms across cancer lineages are Regulation of hippo signaling, Vesicle-mediated transport to the plasma membrane, and Endosomal transport. Each is linked with PACS1 in more than 15 cancer types. Because this analysis shows association rather than direction, both PACS1-to-partner and partner-to-PACS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by PACS1-low versus PACS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS1→partner) and Y-score (partner→PACS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of hippo signaling →	+0.112	+1.292	<.001	<.001	3	16
STOMACH	Vesicle-mediated transport to the plasma membrane →	+0.071	+1.462	<.001	<.001	3	15
LARGE_INTESTINE	Endosomal transport →	+0.059	+1.314	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Caveola assembly →	+0.185	+1.021	.002	.002	3	13
LARGE_INTESTINE	Cytosolic transport →	+0.073	+1.315	<.001	<.001	3	13
BONE	Positive regulation of plasma membrane repair →	+0.253	+0.753	<.001	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,768 associations by consensus.

Regulation of hippo signaling by PACS1 expression — BONE

Explore this box plot interactively →