PACS1

Across TCGA cell cohorts, PACS1 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PACS1-associated genes across cancer lineages are BMP10, SERPINA7, and C1orf158. Each is linked with PACS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACS1-to-partner and partner-to-PACS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP10 grouped by PACS1-low versus PACS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACS1→partner) and Y-score (partner→PACS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BMP10 →	+0.396	+2.733	.005	.009	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
LARGE_INTESTINE	COCH →	+2.336	+3.212	<.001	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.747	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	CUEDC2 →	+0.751	+3.234	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

BMP10 by PACS1 expression — BLOOD_Leukemia

Explore this box plot interactively →