PACRGL

Across TCGA patient cohorts, PACRGL mutation is significantly associated with the RNA expression of many other genes, with 640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACRGL-associated genes across cancer lineages are OR8B6P, RNU4-16P, and RNU1-119P. Each is linked with PACRGL in more than 1 cancer types. Because this analysis shows association rather than direction, both PACRGL-to-partner and partner-to-PACRGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B6P grouped by PACRGL-low versus PACRGL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACRGL→partner) and Y-score (partner→PACRGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR8B6P →	+0.083	+4.594	<.001	.008	3	2
UCEC	RNU4-16P →	+0.236	+2.375	.006	.005	3	2
COAD	RNU1-119P →	+0.329	+7.409	<.001	<.001	3	2
COAD	RN7SKP110 →	+0.635	+6.003	<.001	.002	3	2
COAD	RNU6-615P →	+1.003	+5.893	<.001	.002	3	2
SKCM	RNU4-45P →	+0.349	+6.810	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 640 associations by consensus.

OR8B6P by PACRGL expression — SKCM

Explore this box plot interactively →