PACRGL

Across TCGA patient cohorts, PACRGL mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACRGL-associated genes across cancer lineages are LKB1, Notch1, and p27_pT198. Each is linked with PACRGL in more than 1 cancer types. Because this analysis shows association rather than direction, both PACRGL-to-partner and partner-to-PACRGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by PACRGL-low versus PACRGL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACRGL→partner) and Y-score (partner→PACRGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LKB1 →	-0.098	-2.584	.048	.011	3	1
UCEC	Notch1 →	+0.141	+2.820	.031	.035	3	1
UCEC	p27_pT198 →	+0.109	+2.584	.028	.011	3	1
UCEC	p62 Lck ligand →	+0.368	+3.009	.015	.019	3	1
UCEC	Cyclin-B1 →	+0.693	+3.169	.008	.018	3	1
UCEC	Cyclin-E2 →	+0.226	+3.009	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LKB1 by PACRGL expression — UCEC

Explore this box plot interactively →