PACC1

Across TCGA pan-cancer cohorts, PACC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PACC1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PACC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PACC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where PACC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	1.000	0.505	.010	25	view →
LSCC	DFS	Median	III,IV	0.503	0.838	.042	7	view →
PDAC	OS	Median	II,III,IV	0.336	0.894	.038	6	view →
GBM	OS	Quartile	All	0.453	0.663	.045	3	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.506	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PACC1–HNSC (OS)

Open the HNSC breakdown →