PACC1

Across TCGA patient cohorts, PACC1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PACC1-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and INPP4B. Each is linked with PACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PACC1-to-partner and partner-to-PACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PACC1-low versus PACC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PACC1→partner) and Y-score (partner→PACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.316	+3.584	.044	.002	3	2
UCEC	4E-BP1 →	+0.475	+3.199	<.001	.009	3	2
UCEC	INPP4B →	-0.372	-3.321	.017	.009	3	1
UCEC	JNK2 →	+0.207	+3.009	.031	.019	3	1
UCEC	C-Raf →	+0.275	+3.459	<.001	.005	3	1
UCEC	Rab11 →	-0.162	-2.459	.020	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by PACC1 expression — UCEC

Explore this box plot interactively →