PACC1

Across TCGA cell cohorts, PACC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,084 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PACC1-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Nuclear pore complex assembly, and Nuclear pore organization. Each is linked with PACC1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PACC1-to-partner and partner-to-PACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by PACC1-low versus PACC1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PACC1→partner) and Y-score (partner→PACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Establishment of protein localization to endoplasmic reticulum membrane →	+0.090	+0.746	.001	.003	3	11
SOFT_TISSUE	Nuclear pore complex assembly →	+0.143	+1.082	<.001	<.001	3	11
BONE	Nuclear pore organization →	+0.178	+1.040	<.001	<.001	3	10
PANCREAS	Heme biosynthetic process →	+0.104	+0.712	<.001	.005	3	9
STOMACH	Regulation of cytokinesis →	+0.048	+0.767	.002	.009	3	9
LUNG_SCLC	Negative regulation of sister chromatid cohesion →	+0.083	+0.515	<.001	.008	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,084 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by PACC1 expression — LUNG_NSCLC_LUSC

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