PABPN1

Across TCGA patient cohorts, PABPN1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPN1-associated genes across cancer lineages are JNK2, MSH2, and MSH6. Each is linked with PABPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPN1-to-partner and partner-to-PABPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PABPN1-low versus PABPN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPN1→partner) and Y-score (partner→PABPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.233	+2.834	.005	.034	3	1
UCEC	MSH2 →	-0.346	-2.433	<.001	.018	3	1
UCEC	MSH6 →	-0.569	-3.459	<.001	.005	3	1
UCEC	p27_pT157 →	-0.050	-1.700	.043	.044	3	1
UCEC	p62 Lck ligand →	+0.286	+2.469	.038	.010	3	1
UCEC	p90 RSK →	+0.182	+3.169	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK2 by PABPN1 expression — UCEC

Explore this box plot interactively →