PABPC5

Across TCGA patient cohorts, PABPC5 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPC5-associated genes across cancer lineages are eIF4E, HER2_pY1248, and PDCD4. Each is linked with PABPC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PABPC5-to-partner and partner-to-PABPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PABPC5-low versus PABPC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC5→partner) and Y-score (partner→PABPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.158	+2.012	.012	.017	3	3
COAD	HER2_pY1248 →	-0.180	-2.309	.039	.033	3	3
COAD	PDCD4 →	-0.487	-2.305	.001	.032	3	3
UCEC	PCNA →	+0.235	+3.169	<.001	<.001	3	3
UCEC	ASNS →	+0.306	+1.222	.002	.032	3	3
LUAD	GAPDH →	+0.572	+3.000	.018	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

eIF4E by PABPC5 expression — COAD

Explore this box plot interactively →