PABPC4L

Across TCGA patient cohorts, PABPC4L mutation is significantly associated with the RNA expression of many other genes, with 2,685 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PABPC4L-associated genes across cancer lineages are PTP4A3, GAS2L1, and MAPK11. Each is linked with PABPC4L in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC4L-to-partner and partner-to-PABPC4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTP4A3 grouped by PABPC4L-low versus PABPC4L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC4L→partner) and Y-score (partner→PABPC4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTP4A3 →	-0.798	-3.896	.003	<.001	3	2
COAD	GAS2L1 →	+0.741	+3.847	<.001	<.001	3	2
UCEC	MAPK11 →	+0.806	+2.914	<.001	.001	3	2
UCEC	NF2 →	+0.481	+2.010	.001	.006	3	2
COAD	PDCD1 →	+0.968	+2.598	<.001	<.001	3	2
COAD	TRGC1 →	+0.263	+2.780	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,685 associations by consensus.

PTP4A3 by PABPC4L expression — COAD

Explore this box plot interactively →