PABPC4L

Across TCGA patient cohorts, PABPC4L mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PABPC4L-associated genes across cancer lineages are INPP4B, ATM, and c-Met_pY1235. Each is linked with PABPC4L in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC4L-to-partner and partner-to-PABPC4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PABPC4L-low versus PABPC4L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC4L→partner) and Y-score (partner→PABPC4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.282	-2.999	.039	.035	3	2
COAD	ATM →	-0.603	-3.321	<.001	.009	3	2
UCEC	c-Met_pY1235 →	+0.072	+2.331	.023	.019	3	2
UCEC	Cyclin-E2 →	+0.218	+3.331	.002	.005	3	2
COAD	eIF4E →	+0.165	+3.182	.018	.009	3	2
COAD	LKB1 →	+0.131	+3.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

INPP4B by PABPC4L expression — UCEC

Explore this box plot interactively →