PABPC4L

Across TCGA cell cohorts, PABPC4L mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PABPC4L-associated genes across cancer lineages are OR5T2, DEFB132, and PRAMEF1. Each is linked with PABPC4L in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC4L-to-partner and partner-to-PABPC4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5T2 grouped by PABPC4L-low versus PABPC4L-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC4L→partner) and Y-score (partner→PABPC4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR5T2 →	+0.020	+5.643	<.001	.002	3	1
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	PRAMEF1 →	+0.032	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GAB4 →	+0.738	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF25 →	+0.006	+5.189	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR5T2 by PABPC4L expression — LUNG_SCLC

Explore this box plot interactively →