PABPC4

Across TCGA patient cohorts, PABPC4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPC4-associated genes across cancer lineages are VHL, ASNS, and MEK1. Each is linked with PABPC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC4-to-partner and partner-to-PABPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PABPC4-low versus PABPC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC4→partner) and Y-score (partner→PABPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.806	-2.584	.010	.011	3	2
UCEC	ASNS →	+0.342	+2.999	.042	.035	3	2
UCEC	MEK1 →	+0.483	+3.459	.004	.005	3	1
UCEC	Notch1 →	+0.161	+3.700	.014	.001	1	2
UCEC	p38-MAPK_pT180_Y182 →	-0.473	-3.000	.024	.036	2	1
UCEC	PDCD4 →	-0.508	-2.990	.020	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

VHL by PABPC4 expression — UCEC

Explore this box plot interactively →