PABPC4

Across TCGA cell cohorts, PABPC4 mutation is significantly associated with the RNA expression of many other genes, with 200 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PABPC4-associated genes across cancer lineages are SCGB1C1, OR2B3, and MS4A13. Each is linked with PABPC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC4-to-partner and partner-to-PABPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by PABPC4-low versus PABPC4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC4→partner) and Y-score (partner→PABPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCGB1C1 →	+0.242	+4.981	<.001	.008	3	2
CNS	OR2B3 →	+0.021	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4M2 →	+0.267	+4.887	<.001	.009	3	1
SKIN	WNT2 →	+0.643	+3.426	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 200 associations by consensus.

SCGB1C1 by PABPC4 expression — CNS

Explore this box plot interactively →