PABPC3

Across TCGA patient cohorts, PABPC3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPC3-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and FASN. Each is linked with PABPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC3-to-partner and partner-to-PABPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PABPC3-low versus PABPC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC3→partner) and Y-score (partner→PABPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.210	-2.558	.003	<.001	3	2
UCEC	EGFR_pY1068 →	-0.237	-1.652	<.001	.005	3	2
COAD	FASN →	+0.597	+3.000	.001	.035	3	2
UCEC	p62 Lck ligand →	+0.230	+1.280	.013	.049	3	2
UCEC	Shc_pY317 →	-0.163	-1.777	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.214	-0.999	.004	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-8 by PABPC3 expression — UCEC

Explore this box plot interactively →