PABPC3

Across TCGA cell cohorts, PABPC3 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PABPC3-associated genes across cancer lineages are G6PC, CXorf51A, and TAFA1. Each is linked with PABPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC3-to-partner and partner-to-PABPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PC grouped by PABPC3-low versus PABPC3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC3→partner) and Y-score (partner→PABPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	G6PC →	+0.006	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.076	+4.887	<.001	.009	3	1
BLOOD_Leukemia	TAFA1 →	+0.509	+4.034	.003	.001	3	1
BLOOD_Leukemia	NKAIN3 →	+0.244	+3.007	.007	.007	3	1
OVARY	VWA5B1 →	+0.029	+3.263	<.001	.006	3	1
LARGE_INTESTINE	MTFMT →	+0.492	+2.502	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

G6PC by PABPC3 expression — SKIN

Explore this box plot interactively →