PABPC1L

Across TCGA patient cohorts, PABPC1L mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PABPC1L-associated genes across cancer lineages are Chk2_pT68, INPP4B, and eIF4E. Each is linked with PABPC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC1L-to-partner and partner-to-PABPC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by PABPC1L-low versus PABPC1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC1L→partner) and Y-score (partner→PABPC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.154	-2.000	.035	.010	3	2
COAD	INPP4B →	-0.408	-2.991	.035	.036	3	2
UCEC	eIF4E →	+0.202	+3.584	.014	.002	3	1
UCEC	eIF4G →	+0.254	+3.459	.037	.005	3	1
UCEC	Notch1 →	+0.122	+3.183	.027	.009	3	1
UCEC	p62 Lck ligand →	+0.366	+2.469	.004	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Chk2_pT68 by PABPC1L expression — UCEC

Explore this box plot interactively →