PABPC1L

Across TCGA cell cohorts, PABPC1L mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PABPC1L-associated genes across cancer lineages are PGK2, EDN3, and FSHB. Each is linked with PABPC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC1L-to-partner and partner-to-PABPC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGK2 grouped by PABPC1L-low versus PABPC1L-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC1L→partner) and Y-score (partner→PABPC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
BLOOD_Lymphoma	EDN3 →	+0.026	+3.087	<.001	.009	3	1
BLOOD_Lymphoma	FSHB →	+0.007	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	DEFA4 →	+0.086	+3.169	<.001	.008	3	1
LUNG_NSCLC_LUAD	PDHA2 →	+0.062	+4.662	<.001	.005	3	1
SKIN	ADH4 →	+0.136	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PGK2 by PABPC1L expression — SOFT_TISSUE

Explore this box plot interactively →