PABPC1

Across TCGA cell cohorts, PABPC1 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PABPC1-associated genes across cancer lineages are PCARE, C8orf86, and OR52K1. Each is linked with PABPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PABPC1-to-partner and partner-to-PABPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCARE grouped by PABPC1-low versus PABPC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PABPC1→partner) and Y-score (partner→PABPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PCARE →	+0.038	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	C8orf86 →	+0.017	+4.191	.001	.007	3	1
BLOOD_Lymphoma	OR52K1 →	+0.016	+5.169	<.001	.001	3	1
BLOOD_Lymphoma	SPATS1 →	+0.939	+4.714	<.001	.002	3	1
CNS	CCL1 →	+0.414	+4.472	<.001	.004	3	1
CNS	PRAMEF12 →	+0.535	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

PCARE by PABPC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →