PAAF1

Across TCGA pan-cancer cohorts, PAAF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PAAF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PAAF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAAF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where PAAF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAAF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.690	<.001	12	view →
KICH	Female	All	−1.006	<.001	9	view →
LIHC	Male	All	+0.756	<.001	9	view →
COAD	Female	All	+0.740	<.001	9	view →
HNSC	All	III,IV	+0.524	<.001	9	view →
LUAD	Male	All	+0.491	<.001	8	view →
LUSC	All	II,III,IV	+0.585	<.001	6	view →
BRCA	All	III,IV	+0.430	.002	6	view →
CHOL	All	All	+0.988	<.001	2	view →
STAD	All	II,III,IV	+0.327	.026	2	view →
THCA	Male	IV	−0.310	.017	2	view →
ESCA	Female	All	−0.696	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PAAF1–KIRC

Open the KIRC breakdown →