PA2G4

Across TCGA patient cohorts, PA2G4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PA2G4-associated genes across cancer lineages are 14-3-3_beta, Annexin-1, and EGFR_pY1068. Each is linked with PA2G4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PA2G4-to-partner and partner-to-PA2G4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PA2G4-low versus PA2G4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PA2G4→partner) and Y-score (partner→PA2G4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.109	-3.143	.016	.018	3	2
UCEC	Annexin-1 →	+0.540	+2.189	.023	.034	3	2
UCEC	EGFR_pY1068 →	-0.323	-2.700	.004	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.459	.010	.019	3	1
UCEC	Shc_pY317 →	-0.196	-3.169	.004	.019	3	1
UCEC	Src_pY416 →	-0.215	-1.986	.048	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by PA2G4 expression — UCEC

Explore this box plot interactively →