P4HTM

Across TCGA pan-cancer cohorts, P4HTM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated P4HTM data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher P4HTM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated P4HTM expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where P4HTM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.672	1.000	.014	7	view →
PDAC	OS	Quartile	II,III,IV	0.448	0.681	.020	6	view →
HNSC	DFS	Median	III,IV	0.822	0.529	.024	4	view →
GBM	OS	Quartile	All	0.819	0.909	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

P4HTM–LUAD (DFS)

Open the LUAD breakdown →