P4HTM

Across TCGA patient cohorts, P4HTM protein abundance is significantly associated with the RNA expression of many other genes, with 5,854 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible P4HTM-associated genes across cancer lineages are KCTD6, NDUFAF3, and DALRD3. Each is linked with P4HTM in more than 2 cancer types. Because this analysis shows association rather than direction, both P4HTM-to-partner and partner-to-P4HTM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P4HTM versus KCTD6 in BRCA, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HTM→partner) and Y-score (partner→P4HTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KCTD6 →	+1.028	+0.259	<.001	<.001	3	3
BRCA	NDUFAF3 →	+0.577	+0.248	<.001	<.001	3	3
BRCA	DALRD3 →	+0.626	+0.272	<.001	<.001	3	3
OV	DACT3 →	-0.594	-0.327	.005	.003	3	3
BRCA	SMIM22 →	+1.296	+0.287	<.001	.001	3	3
OV	IP6K2 →	+0.429	+0.406	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,854 associations by consensus.

P4HTM vs KCTD6 — BRCA

Explore this scatter interactively →