P4HTM

Across TCGA patient cohorts, P4HTM mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HTM-associated genes across cancer lineages are ERK2, Notch1, and Rictor_pT1135. Each is linked with P4HTM in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HTM-to-partner and partner-to-P4HTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by P4HTM-low versus P4HTM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HTM→partner) and Y-score (partner→P4HTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.191	+2.321	.048	.035	3	1
UCEC	Notch1 →	+0.154	+2.817	.029	.036	3	1
UCEC	Rictor_pT1135 →	-0.105	-2.321	.042	.035	3	1
UCEC	Caspase-8 →	-0.260	-2.973	.039	.035	3	1
UCEC	cIAP →	+0.196	+3.486	.004	.002	3	1
UCEC	Cyclin-B1 →	+0.708	+2.321	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by P4HTM expression — UCEC

Explore this box plot interactively →