P4HTM

Across TCGA cell cohorts, P4HTM mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P4HTM-associated genes across cancer lineages are OR1L3, C1QL2, and EPPIN. Each is linked with P4HTM in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HTM-to-partner and partner-to-P4HTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by P4HTM-low versus P4HTM-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HTM→partner) and Y-score (partner→P4HTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	2
LARGE_INTESTINE	C1QL2 →	+0.006	+4.684	.004	.002	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	C1orf87 →	+0.025	+5.201	<.001	.006	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR1L3 by P4HTM expression — SKIN

Explore this box plot interactively →