P4HTM

Across TCGA cell cohorts, P4HTM mutation is significantly associated with the mutation status of many other genes, with 2,728 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P4HTM-associated genes across cancer lineages are ALDH16A1, BCL6B, and AXDND1. Each is linked with P4HTM in more than 2 cancer types. Because this analysis shows association rather than direction, both P4HTM-to-partner and partner-to-P4HTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALDH16A1 grouped by P4HTM-low versus P4HTM-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HTM→partner) and Y-score (partner→P4HTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ALDH16A1 →	+4.392	+4.392	.009	.009	1	3
SKIN	BCL6B →	+4.977	+5.638	<.001	<.001	1	3
BLOOD_Leukemia	AXDND1 →	+3.145	+3.932	.004	.004	1	3
BLOOD_Leukemia	GPR101 →	+5.560	+4.736	.003	.003	1	3
BLOOD_Leukemia	PDE3A →	+4.145	+4.635	.001	.001	1	3
BLOOD_Leukemia	PACS1 →	+2.823	+3.665	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,728 associations by consensus.

ALDH16A1 by P4HTM expression — SKIN

Explore this box plot interactively →