Across TCGA patient cohorts, P4HB RNA expression is significantly associated with the protein abundance of many other proteins, with 19,525 significant associations in total. GBM shows the largest number of these associations.

The most reproducible P4HB-associated proteins across cancer lineages are SLC16A3, P4HA1, and P4HA2. Each is linked with P4HB in more than 6 cancer types. Because this analysis shows association rather than direction, both P4HB-to-partner and partner-to-P4HB results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HB→partner) and Y-score (partner→P4HB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC16A3 →	+0.666	+0.731	<.001	<.001	3	7
GBM	P4HA1 →	+0.563	+0.319	<.001	<.001	3	7
GBM	P4HA2 →	+0.912	+0.520	<.001	<.001	3	7
GBM	IKBIP →	+0.809	+0.573	<.001	<.001	3	6
GBM	PLOD1 →	+0.730	+0.494	<.001	<.001	3	6
GBM	PLOD2 →	+0.921	+0.442	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,525 associations by consensus.

Exploration

P4HB survival (RNA) · tumor vs normal (RNA) · all P4HB data types