Across TCGA patient cohorts, P4HB protein abundance is significantly associated with the RNA expression of many other genes, with 19,869 significant associations in total. GBM shows the largest number of these associations.

The most reproducible P4HB-associated genes across cancer lineages are SECISBP2, CEP68, and TSEN2. Each is linked with P4HB in more than 7 cancer types. Because this analysis shows association rather than direction, both P4HB-to-partner and partner-to-P4HB results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HB→partner) and Y-score (partner→P4HB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SECISBP2 →	-0.661	-0.363	<.001	<.001	3	8
COAD	CEP68 →	-0.535	-0.261	<.001	<.001	3	7
LSCC	TSEN2 →	-0.452	-0.246	<.001	<.001	3	7
HNSC	XPA →	-0.511	-0.167	.001	<.001	3	7
LSCC	YPEL1 →	-0.556	-0.259	.001	<.001	3	6
OV	KDELR3 →	+1.520	+0.765	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,869 associations by consensus.

Exploration

P4HB survival (RNA) · tumor vs normal (RNA) · all P4HB data types