Across TCGA patient cohorts, P4HB mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HB-associated genes across cancer lineages are PCNA, c-Kit, and 14-3-3_beta. Each is linked with P4HB in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HB-to-partner and partner-to-P4HB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HB→partner) and Y-score (partner→P4HB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.231	+2.906	.011	.001	3	2
UCEC	c-Kit →	-0.197	-2.222	.046	.011	3	2
UCEC	14-3-3_beta →	-0.108	-3.143	.011	.018	3	1
UCEC	eEF2 →	+0.356	+2.999	.019	.035	3	1
UCEC	EGFR_pY1068 →	-0.320	-2.906	.002	.001	3	1
UCEC	eIF4E →	+0.184	+2.820	.040	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

P4HB survival (RNA) · tumor vs normal (RNA) · all P4HB data types