P4HB

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, P4HB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,382 significant associations in total. BONE shows the largest number of these associations.

The most reproducible P4HB-associated GO terms across cancer lineages are Protein exit from endoplasmic reticulum, Regulation of translation initiation in response to endoplasmic reticulum stress, and Biological process involved in symbiotic interaction. Each is linked with P4HB in more than 14 cancer types. Because this analysis shows association rather than direction, both P4HB-to-partner and partner-to-P4HB results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HB→partner) and Y-score (partner→P4HB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BONEProtein exit from endoplasmic reticulum →+0.113+0.883<.001<.001315
LIVERRegulation of translation initiation in response to endoplasmic reticulum stress →+0.167+0.936<.001.001315
BONEBiological process involved in symbiotic interaction →+0.093+0.941<.001<.001315
SOFT_TISSUEPositive regulation of protein exit from endoplasmic reticulum →+0.142+1.121<.001<.001315
CNSCOPII-coated vesicle cargo loading →+0.139+1.003<.001<.001315
BONEGlycoprotein biosynthetic process →+0.074+1.175<.001.001315
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,382 associations by consensus.

Exploration