Across TCGA cell cohorts, P4HB mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P4HB-associated genes across cancer lineages are IL31, MDFIC2, and PGLYRP3. Each is linked with P4HB in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HB-to-partner and partner-to-P4HB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HB→partner) and Y-score (partner→P4HB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
CNS	PGLYRP3 →	+0.602	+5.754	<.001	.002	3	1
CNS	SMCP →	+0.197	+5.321	<.001	.005	3	1
CNS	OR1G1 →	+0.029	+5.754	<.001	.002	3	1
CNS	KRTAP19-2 →	+0.128	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

P4HB survival (RNA) · tumor vs normal (RNA) · all P4HB data types