P4HA3

Across TCGA pan-cancer cohorts, P4HA3 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated P4HA3 data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher P4HA3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated P4HA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, PRAD, and SARC are the cancer types where P4HA3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SARC	DFS	Median	All	0.081	0.632	<.001	3	view →
STAD	DFS	Median	III,IV	0.149	0.606	.004	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →
UCEC	DFS	Median	All	1.000	0.831	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

P4HA3–MESO (DFS)

Open the MESO breakdown →