P4HA3

Across TCGA pan-cancer cohorts, P4HA3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated P4HA3 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher P4HA3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated P4HA3 expression acts as an unfavorable survival marker.

PDAC, LSCC, and LUAD are the cancer types where P4HA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.188	0.914	.002	15	view →
LSCC	DFS	Quartile	II,III,IV	0.506	0.926	.008	8	view →
LUAD	OS	Tertile	II,III,IV	0.255	1.000	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

P4HA3–PDAC (DFS)

Open the PDAC breakdown →