P4HA2

Across TCGA pan-cancer cohorts, P4HA2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated P4HA2 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher P4HA2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated P4HA2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where P4HA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.710	0.946	<.001	108	view →
PDAC	OS	Quartile	All	0.266	0.518	.008	38	view →
GBM	DFS	Quartile	All	0.600	0.880	.008	12	view →
LSCC	DFS	Tertile	All	0.616	0.837	.018	10	view →
LUAD	OS	Tertile	III,IV	0.717	1.000	.004	10	view →
UCEC	DFS	Median	II,III,IV	0.865	0.550	.027	4	view →
HNSC	DFS	Median	II,III,IV	0.562	0.736	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

P4HA2–CCRCC (OS)

Open the CCRCC breakdown →