P4HA2

Across TCGA patient cohorts, P4HA2 mutation is significantly associated with the RNA expression of many other genes, with 2,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HA2-associated genes across cancer lineages are TSPY19P, GYG2P1, and DPP4-DT. Each is linked with P4HA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HA2-to-partner and partner-to-P4HA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY19P grouped by P4HA2-low versus P4HA2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA2→partner) and Y-score (partner→P4HA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	TSPY19P →	+0.119	+7.939	<.001	.008	3	2
UCEC	GYG2P1 →	+0.024	+1.578	<.001	.005	3	2
UCEC	DPP4-DT →	+0.226	+1.535	.006	.004	3	2
UCEC	EIF4EBP1P1 →	+0.187	+1.722	.009	<.001	3	2
UCEC	MIR5581 →	+0.546	+1.584	.007	.006	3	1
UCEC	MIR3927 →	+0.103	+3.247	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,066 associations by consensus.

TSPY19P by P4HA2 expression — PRAD

Explore this box plot interactively →