P4HA2

Across TCGA cell cohorts, P4HA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,497 significant associations in total. BONE shows the largest number of these associations.

The most reproducible P4HA2-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, Viral process, and Integrin-mediated signaling pathway. Each is linked with P4HA2 in more than 16 cancer types. Because this analysis shows association rather than direction, both P4HA2-to-partner and partner-to-P4HA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by P4HA2-low versus P4HA2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA2→partner) and Y-score (partner→P4HA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.135	+3.468	<.001	<.001	3	17
STOMACH	Viral process →	+0.106	+2.802	<.001	<.001	3	16
BONE	Integrin-mediated signaling pathway →	+0.254	+3.199	<.001	<.001	3	16
BONE	COPII-coated vesicle cargo loading →	+0.123	+3.154	<.001	<.001	3	15
SOFT_TISSUE	Negative regulation of immune response →	+0.098	+2.078	<.001	<.001	3	15
BONE	Extracellular matrix organization →	+0.192	+3.261	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,497 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by P4HA2 expression — BONE

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