P4HA1

Across TCGA pan-cancer cohorts, P4HA1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of P4HA1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where P4HA1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types P4HA1 is over-expressed in tumor.

CCRCC, HNSC, and COAD are the cancer types where P4HA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P4HA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+1.852	<.001	12	view →
HNSC	All	IV	+1.354	<.001	12	view →
COAD	Female	III,IV	+1.064	<.001	11	view →
LUAD	Male	III,IV	+1.348	<.001	9	view →
LSCC	All	III,IV	+1.297	<.001	9	view →
PDAC	Female	II,III,IV	+1.224	<.001	8	view →
OV	All	All	+0.984	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

P4HA1–CCRCC

Open the CCRCC breakdown →