P4HA1

Across TCGA patient cohorts, P4HA1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,767 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible P4HA1-associated genes across cancer lineages are PLOD2, PFKFB4, and ENO2. Each is linked with P4HA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both P4HA1-to-partner and partner-to-P4HA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P4HA1 versus PLOD2 in PDAC, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA1→partner) and Y-score (partner→P4HA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLOD2 →	+1.157	+0.836	<.001	<.001	3	10
UCEC	PFKFB4 →	+1.020	+0.396	<.001	<.001	3	9
PDAC	ENO2 →	+1.113	+0.838	<.001	<.001	3	8
OV	NDUFA4L2 →	+1.426	+0.471	<.001	<.001	3	8
PDAC	PGK1 →	+0.851	+0.781	<.001	<.001	3	8
GBM	COL1A1 →	+1.877	+0.616	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,767 associations by consensus.

P4HA1 vs PLOD2 — PDAC

Explore this scatter interactively →